Perform inoculum expansion and cell bank generation
Execute cell culture experiments using Ambr250 and 2L bioreactors
Perform pilot scale material generation using 50L, 200L and 500L single use bioreactors
Execute small scale and pilot scale depth filtration and centrifugation primary recovery processes
Perform tech transfer of Master cell bank generation, cell culture and primary recovery processes to the GMP manufacturing facilities
Provide person-in-plant support at the GMP manufacturing facility
Perform cell culture experiments to optimize N-1 perfusion processes as well as intensified fed-batch processes
Represent the cell culture development group for pipeline projects in cross-functional meetings and collaborate closely with cell line, purification, analytical and formulation development leads to meet project timelines
Author and review technical reports, GMP campaign summary reports, and relevant sections in regulatory filings
Proactively identify and implement opportunities to optimize platform processes and deepen process understanding
Present scientific findings at internal or external conferences
Collaborate effectively with colleagues to promote a positive and efficient laboratory environment, and actively contribute ideas to enhance lab workflows and practices
Required
Scientific degree in chemical engineering, bioengineering, biotechnology, or a related field. A minimum of 2 years for M.S. or 5 years for B.S. graduates
Proficient in aseptic techniques
Experience in developing and executing mammalian suspension cell culture processes in shake flasks, Ambr250 and 2L bioreactors
Strong understanding of mammalian cell and molecular biology and cell culture bioprocess engineering concepts
Strong attention to detail; active and quick learner; able to change courses quickly as needed, raises the bar and is never satisfied with the status quo; opens to suggestions and embraces the ideas of others; actively builds relationships with others
Experience in technical report authoring and reviewing
Proficient with Microsoft Office software (Word, Excel, and PowerPoint) and statistical modelling software such as JMP
Preferred:
Experience in perfusion technology, especially Alternating Tangential flow filtration (ATF) at bench
Experience in pilot scale operations including 50L, 200L, 500L Single-use systems, and harvest operations
Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law:
We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees.
This job is eligible to participate in our short-term incentive programs.
AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community. Equal Opportunity Employer/Veterans/Disabled.
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Dental insuranceVision insurance401(k)Paid time offPerformance bonus
Additional Information
The Cell Culture Development Group in South San Francisco, CA is seeking a Scientist I to join a talented and collaborative team to develop cell culture processes for GMP applications.
In this position, you will perform cell culture process development, scale-up, and technology transfer activities in a well-supported and dynamic environment to help advance novel biotherapeutics into human clinical studies.
Abbvie · San Francisco, CA