Associate Principal Scientist, Discovery Oncology

External

Merck · - California - South San Francisco (grand Ave)

Full-timeOn-siteToday

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Responsibilities

Design, establish, and optimize in vitro and ex vivo assays to elucidate mechanisms of action and assess therapeutic potential.
Make timely, data-driven decisions that balance innovation, risk, and experimental rigor
Communicate scientific strategy, rationale, and results clearly to internal teams and help build external scientific presence through publications, conference presentations, and collaboration
Drive ideation and early-stage discovery efforts to deliver competitive oncology programs, leveraging internal expertise and emerging technologies

Requirements

Education:

Ph.D. in Cancer Biology, Cell Biology, Pharmacology, Immunology, Biochemistry, or a related discipline with four (4) or more years of relevant oncology drug discovery experience

Required Experience and Skills:

Deep expertise in tumor biology and immune oncology, including cancer genomics and oncogenic signaling

Broad technical expertise in molecular and cellular biology, biochemistry, and analytical methods

Extensive hands-on in vitro experience designing, executing, and analyzing multi-color flow cytometry and mechanistic cell-based assays (e.g., viability/cytotoxicity, cell cycle, signaling, and immune response readouts)

Demonstrated ability to drive innovative research, evidenced by high-impact publications, patents, and/or successful advancement of discovery programs

Passionate, creative, and collaborative scientist committed to improving outcomes for people living with cancer

Excellent oral and written communication skills, a positive, team-oriented mindset, and strong leadership potential

Preferred Experience and Skills:

Hands-on experience with different therapeutic modalities (e.g.,small molecules, mAbs, ADCs and TCEs)

Extensive hands-on experience designing, executing, and analyzing in vivo mouse model data to evaluate therapeutics

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Required Skills:

Biochemistry, Cancer Cell Biology, Cancer Research, Cell Biology, Immuno-Oncology, In Vitro Biology, In Vitro Research, In Vitro Studies, Molecular Biology, Oncology, Tumor Biology

Preferred Skills:

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The salary range for this role is

$159,600.00 - $251,200.00

The successful candidate will be eligible for annual bonus and long-term incentive, if applicable.

Associate Principal Scientist, Discovery Oncology

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