Research Assistant - Advanced mRNA Therapeutics (Fixed Term)

About the role

Location: Central Cambridge Advanced mRNA therapeutics offer a powerful way to transiently express proteins that can reshape immune signalling in vivo. This role will focus on designing and manufacturing modified mRNAs encoding proteins that modulate IL-6 signalling, and testing their biological activity in cellular and animal models. We are looking to appoint a Research Assistant to work across mRNA therapeutic design, in vitro transcription, lipid nanoparticle formulation, immune signalling assays and in vivo mouse experiments, with the aim of defining whether engineered mRNA medicines can be used to tune IL-6-dependent immune responses for therapeutic benefit. The successful candidate will be expected to work with a high degree of technical independence across the full experimental workflow: design and production of IVT mRNA constructs, capping and polyadenylation, LNP formulation, in vitro testing of IL-6 pathway activity, and in vivo assessment in mouse models. Candidates must have a degree in a relevant biological science The role requires a strong practical understanding of mRNA therapeutic development, IL-6 biology and animal experimentation, including current UK Home Office personal licence authority and demonstrable expertise in mouse handling. The project will suit a technically skilled and scientifically engaged researcher who can move confidently between molecular biology, immunology and in vivo experimentation, and who is able to generate robust, reproducible data in a fast-moving translational research environment. This position also offers the potential for the successful candidate to study for a PhD alongside their employment (subject to the University Admissions policy). Fixed-term: The funds for this post are available for 3 years in the first instance. To apply online for this vacancy and to view further information about the role, please click 'Apply' above. Further information about the Toxicology Unit can be found on our website: https://www.mrc-tox.cam.ac.uk Please quote reference PU49864 on your application and in any correspondence about this vacancy. The University actively supports equality, diversity and inclusion and encourages applications from all sections of society. The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

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