Execute in vitro DMPK assays, including plasma protein binding, microsomal stability incubations, hepatocyte metabolism studies, and permeability assessments in cell monolayers.
Conduct in vivo PK studies, dosing by various standard routes, terminal and non-terminal blood sampling, and organ/tissue collection.
Develop and/or prepare preclinical formulations by dissolving or suspending test agents for in vivo dosing.
Analyze data, maintain accurate records (LIMS, lab notebooks, reports), and communicate results to the Director and project team in a fast-paced environment.
Performs other related duties as assigned in order to meet the goals of the department and institution.
Maintains regular and predictable attendance.
Requirements
Demonstrated experience with LC-MS/MS bioanalysis for small molecules.
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Additional Information
The Senior Scientist or Scientist conducts laboratory-based studies under the general guidance of the Director. Independently designs and executes experiments to support drug discovery and development efforts within the area of expertise. Analyzes and interprets data, refines experimental approaches, and contributes to the communication and reporting of research findings.
Position Summary
We are seeking a highly motivated, hands-on scientist to join our academically-oriented team supporting primarily small-molecule drug discovery and development. This laboratory-based role requires direct execution of bioanalytical, in vitro DMPK, and in vivo PK studies. The successful candidate will have a track record of executing such work directly rather than managing or outsourcing it. This is a bench-focused position emphasizing practical, experimental work across a DMPK-style workflow in an academic, non-profit environment.
Stjude · Memphis, TN