Principal Research Scientist (LC-MS/MS)

About the role

As an LC-MS Principal Research Scientist, you will serve as an industry expert for pre-clinical GLP bioanalytical study method development, validation, sample analysis utilizing triple quadrupole LC-MS systems. You will serve as the expert for ADCs and large molecule LC-MS/MS analytical assays and sample preparation. Responsible for direct interaction with clients, report writing, and adherence to regulatory guidelines. You will collaborate with other scientists, analysts, and departments in a team-oriented environment. You will possess knowledge and experience in a Good Laboratory Practice (GLP) environment and be able to adhere to GLP guidelines and practices. What You'll Do Here Provide technical and scientific expertise for small and large molecule analysis via LC-MS/MS. Ensure all work is operating in full compliance to GLP requirements, protocols, and SOPs. Maintain open and direct communication and attend recurring calls with clients as needed. Serve as principal investigator or contributing scientist for LC-MS/MS studies. Prepare all necessary driving documents for in-lab analysis. Complete and deliver scientific reports to clients on time. Prepare materials, including animal blood and tissues, for analytical assays to be run on LC-MS/MS instrumentation. Maintain and document chain of custody for specimens, reagents, controls, and samples in the laboratory. Perform the assays according to protocol or other guiding documents with accurate documentation. Maintain and update facility records related to the laboratory and its analyses. Review laboratory records, procedures, and study data for completeness and accuracy. Assist in calibration, optimization, maintenance, and collection of data from analytical instruments. Perform routine laboratory maintenance (including cleaning, stocking supplies, equipment maintenance tasks, etc.). Document deviations to laboratory procedures and study protocols in a timely manner and provide input for corrective actions. Collaborate with internal regulatory departments to ensure quality and compliance oversight on GLP studies. Follow Altasciences' Standard Operating Procedures (SOPs), ensure compliance with GLP, FDA's ICH M10 guidelines, ALCOA+, USDA, and AAALAC guidelines, and can identify areas for improvement. What You'll Need to Succeed Minimum Requirements Bachelor's degree in Immunology/Biology/Chemistry or other scientific related discipline plus a minimum of 5 years of relevant GLP laboratory experience. Experience in a Good Laboratory Practices (GLP) and CRO environment. Experience with LC-MS/MS instrumentation and software. Ability to handle multiple projects, prioritize work, and meet deadlines. Preferred Requirements Master's degree or PhD in scientific related discipline. Ideally a minimum of 5 years as Senior Research Scientist or equivalent in a GLP environment. Experience with Shimadzu and SCIEX instrumentation. Experience with Watson.