Principal Scientist, Process Chemistry

About the role

Calico (Calico Life Sciences LLC) is an Alphabet-founded research and development company whose mission is to harness advanced technologies and model systems to increase our understanding of the biology that controls human aging. Calico will use that knowledge to devise interventions that enable people to lead longer and healthier lives. Calico's highly innovative technology labs, its commitment to curiosity-driven discovery science and, with academic and industry partners, its vibrant drug-development pipeline, together create an inspiring and exciting place to catalyze and enable medical breakthroughs. Position Description: Calico is seeking an experienced Process Chemist to join our laboratory-based chemical development team. The ideal candidate brings extensive hands-on experience in process research, route scouting, and scale-up of organic molecules. In this role, you will design, optimize, and execute synthetic processes that enable efficient, safe, and scalable manufacturing of small-molecule intermediates and APIs. This is a lab-focused position requiring strong experimental skills, deep organic chemistry knowledge, and the ability to translate laboratory findings into robust processes.