Own the Calci brand strategy end-to-end - positioning, messaging architecture, segmentation, and go-to-market sequencing - ensuring full alignment from pre-NDA approval through Year 1+ commercialization
Lead all brand planning milestones, including annual brand plan, launch readiness assessments, and BOD-level commercial reporting
Serve as the senior commercial voice on the Calci Product Team, embedding market realities into cross-functional planning across Medical Affairs, Regulatory, Market Access, and Patient Advocacy
Build and maintain a dynamic competitive intelligence function, monitoring the ADH1 and broader hypoparathyroidism landscape and translating findings into strategic decisions
Partner with Value & Access to shape the payer value proposition and ensure access strategies are integrated into brand planning from day one
People Leadership & Team Development
Directly lead and develop a team of 4, including: Director, HCP Marketing; Director, Patient Marketing; and two KOL Engagement Leads - setting individual performance goals, coaching toward professional growth, and building a cohesive, high-performing marketing organization
Foster a culture of intellectual rigor, creative ambition, and patient-first accountability across the marketing team
Act as the connector between team workstreams, ensuring HCP, patient, and KOL strategies are mutually reinforcing and aligned under one brand narrative
Develop the next generation of commercial talent within the team through active mentorship, stretch assignments, and transparent performance management
HCP Marketing
Oversee the development of a field-ready HCP promotional platform - including clinical messaging, EAM enablement tools, and channel strategy - built on deep insight into endocrinologist and nephrologist decision-making
Ensure EAM (Endocrine Account Manager) engagement materials reflect the Calci scientific story with precision, clarity, and promotional compliance
Lead commercial advisory boards and insight-generation programs to continuously refine HCP strategy and ensure message resonance
Partner with Market Insights to develop HCP segmentation and targeting frameworks, including tiered engagement models for high-value prescribers
Patient Marketing & Disease Awareness
Guide the patient marketing director in developing a robust DTC and patient-facing strategy, with a focus on diagnosis acceleration, disease education, and treatment adherence for ADH1 patients
Oversee the commercial patient support ecosystem in partnership with specialty ph
Additional Information
Mavericks Wanted
When was the last time you achieved the impossible? If that thought feels overwhelming, you might want to pause here, but if it sparks excitement...read on
In 2015, we pioneered a "moneyball for biotech" approach, pooling projects and promising early-stage research from academia together under one financial umbrella to reduce risk and unleash innovation. This model allows science and small teams of experts to lead the way. We build bridges to groundbreaking advancements in rare disease, and develop life-changing medicines for patients with unmet needs as fast as humanly possible.
Together we define white space, push boundaries, and empower people to solve problems. If you're someone who defies convention, join us and work alongside some of the most respected minds in the industry. Together, we'll ask "why not?" and help reengineer the future of biopharma. At BridgeBio, we value curiosity and experimentation-including the ethical & thoughtful use of AI to improve clarity, speed, and quality of work.
Position Summary
You are a seasoned rare disease commercialization leader who thrives at the intersection of science, strategy, and execution. You have led - or been a critical architect of - at least one rare disease launch, and you understand that in a small-patient, high-science category, every HCP interaction and every patient touchpoint matters. You know how to build a brand from the ground up, how to mobilize a field team around a clear and compelling narrative, and how to make the most of a narrow but deep opportunity.
The Senior Director, Head of Marketing will serve as the commercial brand authority for Calci (encaleret) - BridgeBio's oral CaSR negative allosteric modulator in NDA review for Autosomal Dominant Hypocalcemia Type 1 (ADH1). This is a first-in-class asset targeting a chronically underserved rare endocrine population, and this role represents a defining commercial leadership opportunity. You will own the full marketing function for Calci: leading HCP marketing, patient marketing, and KOL engagement under a single integrated brand strategy. You will report directly to the SVP, Sales & Marketing - Endocrinology and will be expected to be on-site in both our San Francisco and Palo Alto home offices on a weekly basis.
This is not a role for someone who needs a playbook. It's a role for someone who writes one.
Bridgebio · San Francisco - 1800 Owens