Scientist /Senior Scientist, Aging Biology

External

Calicolabs · South San Francisco, CA

$156K–$191K/yrFull-timeOn-site3w ago

Data AnalysisDocumentationLeadershipPython

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About the role

Calico (Calico Life Sciences LLC) is an Alphabet-founded research and development company whose mission is to harness advanced technologies and model systems to deepen our understanding of the biology that controls human aging. Calico aims to use that knowledge to devise interventions that enable people to lead longer and healthier lives. Calico's highly innovative technology labs, its commitment to curiosity-driven discovery science, and, with academic and industry partners, its vibrant drug-development pipeline, together create an inspiring and exciting place to catalyze and enable medical breakthroughs. Position Description: We are seeking a highly motivated and creative Scientist/Senior Scientist, Aging Biology to join our Translational Medicine team. This role is pivotal in elucidating the mechanism of action (MOA) of therapeutic targets within our aging biology pipeline. The successful candidate will be responsible for defining the molecular and cellular pathways that are fundamental to the program's biology. This role is critical for translating novel in vivo findings into a deep mechanistic understanding to guide its path toward clinical development. The ideal candidate will bring deep expertise in cell biology, MOA studies, and complex signaling pathways to this challenge.

Responsibilities

Independently design and lead experimental strategies to elucidate the molecular and cellular mechanisms of action for aging targets and biomarkers, generating insights that guide program direction

Conduct in vitro and ex vivo studies to investigate target biology in key aging-related processes, including stem cell function, tissue repair, and signaling or transcriptional regulation

Compare acute and chronic pathway modulation in tissue injury and aging models to understand how stress responses and repair mechanisms evolve with age

Investigate the molecular drivers of in vivo phenotypes in preclinical aging models to identify biomarkers and translatable mechanisms relevant to clinical development

Collaborate with in vivo pharmacology and biomarker teams to select and leverage preclinical models that best probe target biology

Partner with cross-functional groups (e.g., Biomarkers, Genomics, Protein Sciences) to integrate multi-omic datasets and build a comprehensive mechanistic framework

Analyze, interpret, and present complex data and strategic recommendations to internal project teams and senior leadership

Maintain rigorous experimental documentation and contribute to internal reports, publications, and regulatory submissions

Position Requirements:

Ph.D. in Cell Biology, Molecular Biology, Physiology, or a related field, with 2-5 years (for Scientist level) or 5+ years (for Senior Scientist level) of relevant industry or post-doctoral experience

Demonstrated expertise in designing and executing complex experiments to elucidate mechanisms of action in age-related disease models

Strong hands-on experience with a range of cellular and molecular biology techniques (e.g., primary cell culture, flow cytometry, single-cell RNAseq, qPCR, Western blot, ELISA, functional assays)

Proven ability to think critically and solve complex biological problems

Strong data analysis skills and proficiency with Prism or similar software

Exceptional organizational skills and meticulous attention to detail, with a proven ability to manage complex projects

Strong teamwork and communication skills, with an ability to collaborate effectively in a cross-functional environment

Flexible, able to respond quickly to shifting priorities and to multitask

Must be willing to work onsite five days per week

Scientist /Senior Scientist, Aging Biology

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