Postdoctoral Fellow - Therapeutic Senescence & Tumor Immunology Laboratory of Paul Romesser, MD

About the role

The people of Memorial Sloan Kettering Cancer Center (MSK) are united by a singular mission: ending cancer for life. Our specialized care teams provide personalized, compassionate, expert care to patients of all ages. Informed by basic research done at our Sloan Kettering Institute, scientists across MSK collaborate to conduct innovative translational and clinical research that is driving a revolution in our understanding of cancer as a disease and improving the ability to prevent, diagnose, and treat it. MSK is dedicated to training the next generation of scientists and clinicians, who go on to pursue our mission at MSK and around the globe. Exciting Opportunity at MSK: Postdoctoral fellow Role Overview The Romesser Lab is recruiting a bold, creative, and highly motivated Postdoctoral Fellow to join our team studying therapy-induced senescence, tumor immunology, and translational cancer biology. Our laboratory is focused on turning cellular senescence into a therapeutically actionable immunologic state against cancer. Rooted in rectal cancer, but designed to translate across immune-refractory tumors, our program integrates immunocompetent mouse models, patient-derived organoids, tumor-immune co-culture systems, single-cell and spatial multi-omics, CRISPR-based functional genomics, and deeply annotated clinical specimens. The successful candidate will have the opportunity to develop and lead NIH- and foundation-funded projects that dissect the senescence-immune interface and identify novel combination therapies that can be advanced toward clinical translation. The fellow will be expected to design, execute, optimize, and troubleshoot experiments across in vivo, ex vivo, and patient-derived model systems; integrate mechanistic and translational studies across mouse models, organoids, co-culture platforms, human tumor samples, and clinical biospecimens; analyze and interpret complex datasets; prepare manuscripts; present findings at scientific meetings; contribute to fellowship and grant applications; and collaborate across MSK's scientific community. Our lab has access to exceptional translational resources, including a biobank of more than 500 patient-derived rectal cancer organoids, longitudinal tumor biopsies from patients undergoing therapy, and large clinical trial-associated biospecimen collections, including primary tumor and plasma samples. We are actively developing human organoid and T-cell co-culture systems using matched patient-derived samples, creating a powerful platform to study therapy response, immune resistance, and tumor-immune interactions in clinically relevant models. What makes this opportunity distinctive is the direct connection between mechanistic laboratory science and active clinical investigation. The fellow will be able to move between patient-derived models, mouse systems, single-cell and spatial profiling, CRISPR-based perturbation approaches, and biospecimens from ongoing clinical studies, with the goal of identifying mechanisms of therapy response and translating these findings toward new therapeutic strategies. This position is ideal for a candidate who wants to combine rigorous mechanistic biology with translational impact and who is excited to develop an independent scientific direction within a collaborative, technology-rich environment. Key Requirements PhD, MD/PhD, MD or equivalent doctoral degree in immunology, cancer biology, molecular biology, cell biology, computational biology, or a related field. Strong record of scientific productivity, including first-author publications or clear evidence of major manuscript-level contributions. Demonstrated ability to think critically, generate hypotheses, design experiments, troubleshoot, and interpret data. Experience in at least one relevant area, such as tumor immunology, cancer biology, organoid systems, mouse models, senescence biology, cancer metabolism, CRISPR screening, single-cell/spatial biology, or computational biology. Strong communication skills and enthusiasm for working in a collaborative translational research environment. Application Requirements Core Skills: Experimental Design & Troubleshooting: Ability to conceptualize, execute, optimize, and troubleshoot complex in vivo, ex vivo, and patient-derived model systems, including mouse models, organoids, co-cultures, CRISPR perturbations, and multiplex assays. Tumor Immunology & Translational Biology: Experience with immunological assays such as flow cytometry, ELISA/LEGENDplex, T-cell or myeloid functional assays, tumor-immune co-culture systems, or related approaches. Data Interpretation & Multi-omic Integration: Ability to interpret complex biological datasets, including single-cell, spatial, functional genomics, flow cytometry, immune profiling, and clinical correlative data. Computational Experience Preferred: Experience with R, Python, Seurat, Scanpy, statistical analysis, data visualization, and/or machine learning approaches is p