Senior Principal Scientist

About the role

We now have an exciting opportunity for a Senior Principal Scientist in Process Development to join our team based in Cork, Ireland. The successful candidate will work as part of a multi-disciplinary team working with leading edge technology. As a Senior Principal Scientist, you will serve as a key technical leader driving route scouting, synthetic design, process development, and process characterization for our development programs. You will apply a strong foundation in modern synthetic organic chemistry and process development to build scalable, innovative chemistry using state‑of‑the‑art technologies (HTE, data‑rich experimentation, AI tools, continuous processing, catalysis, and predictive tools). This role provides the opportunity to contribute through hands‑on laboratory innovation while guiding strategy for early and late‑stage programs. You will mentor junior scientists, influence cross‑functional project direction, and represent PDC both internally and externally. The PDC is a vibrant, dynamic team with excellent career development and advancement opportunities. This role will require attendance at our facility in Cork. Reporting to the PDC Lead, the successful candidate's key responsibilities, commensurate with the position: Contribute a range of highly innovative chemistry and process development ideas to support global process development projects. Apply innovative synthetic chemistry and process development skills, new technologies and statistical experimental design approaches to develop safe, efficient, and robust processes including full-scale qualification and/or commercial validation batches meeting contemporary regulatory standards. Apply synthetic chemistry and mechanistic expertise to support commercial API processes at relevant API sites. Demonstrate problem solving by leading chemistry and process understanding. Lead matrix teams of scientists across multiple levels to deliver portfolio and initiative breakthroughs. Lead and contribute to scientific strategy and direction for advances in delivery of 2nd Generation API process development through interaction with organizational thought leaders and cross functional management. Advance scientific research and expand capability in the areas of chemical synthesis and process research and development, including the identification and application of advances in automation, robotics and AI to process development programs. Investigate new technologies and process development approaches to bring added value to Pfizer Global Supply. Contribute to current relevant scientific literature and maintain an awareness of new advances in the field of chemistry. Conduct novel scientific research and present significant findings via internal and external presentations or publications. Provide scientific advances, leadership, and strategic direction for the fundamental understanding of small molecule API chemical synthesis and process development programs. Teach and mentor colleagues across the Pfizer organization. Cultivate sustainable and effective relationships with internal partners and stakeholders, i.e., partner lines in Global Technology Engineering and Launch (GTEL), Pfizer Global Supply (PGS) and Pharmaceutical Sciences Small Molecule (PSSM). Lead key projects in support of SMT initiatives, through cross-functional and divisional teams. Complete reports, memos and eLN experiments to a high standard and meeting required deadlines. Contribute to the PDC chemistry team program of continuous improvem

Benefits

Additional Information

Senior Principal Scientist - Process Development Centre Use Your Power for Purpose At Pfizer, our purpose is to deliver breakthroughs that change patients' lives. Your contributions will directly impact the development of new therapies and vaccines, ultimately improving the lives of patients around the world. By leveraging cutting-edge design and process development capabilities, you will help accelerate the delivery of best-in-class medicines to patients globally. About Pfizer Process Development Centre The Pfizer global Process Development Centre (PDC) is an innovative team which develops novel synthetic routes and scalable chemical API processes and technology for the Pfizer global manufacturing network. Our process chemists, analytical scientists, and chemical engineers collaborate to design robust, safe, and scalable chemistry that accelerates delivery of life‑changing therapeutics to patients. Additionally, the PDC leads and supports various supply assurance projects for the global manufacturing network. Our team works closely with global research and operations teams enabling the manufacture of life saving medicines.

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