Principal Facilities Engineer - Onsite San Diego HQ

About the role

At Neurocrine Biosciences, we pride ourselves on having a strong, inclusive, and positive culture based on our shared purpose and values. We know what it takes to be great, and we are as passionate about our people as we are about our purpose - to relieve suffering for people with great needs. What We Do: Neurocrine Biosciences is a leading neuroscience-focused, biopharmaceutical company with a simple purpose: to relieve suffering for people with great needs. We are dedicated to discovering and developing life-changing treatments for patients with under-addressed neurological, neuroendocrine and neuropsychiatric disorders. The company's diverse portfolio includes FDA-approved treatments for tardive dyskinesia, chorea associated with Huntington's disease, classic congenital adrenal hyperplasia, endometriosis* and uterine fibroids,* as well as a robust pipeline including multiple compounds in mid- to late-phase clinical development across our core therapeutic areas. For three decades, we have applied our unique insight into neuroscience and the interconnections between brain and body systems to treat complex conditions. We relentlessly pursue medicines to ease the burden of debilitating diseases and disorders because you deserve brave science. For more information, visit neurocrine.com , and follow the company on LinkedIn , X and Facebook . ( *in collaboration with AbbVie ) Provides advanced technical expertise for life sciences facilities supporting research, clinical development, and regulated spaces. This role is accountable for the performance, reliability, and compliance of mission-critical facility systems and leads engineering strategies that ensure operational excellence in regulated environments. Leads complex, cross-functional engineering programs and initiatives that impact facility infrastructure, regulatory readiness, and long-term asset performance. The Principal Engineer serves as a key technical resource for infrastructure systems, including laboratory HVAC, process utilities, building automation systems, laboratory and automation equipment, and electrical distribution. This position supports infrastructure performance to enable scientific advancement, product development, and facility operations. In partnership with Facilities, Research and Development, Quality, Validation, Environmental Health & Safety, and Information Technology, this role supports engineering initiatives that improve system reliability, regulatory readiness, and asset performance. Develops and advances engineering standards, best practices, and technical approaches for facilities infrastructure. _ Your Contributions (include, but are not limited to): Leads engineering assessments and drives capital planning activities, including prioritization of infrastructure investments aligned with business and regulatory needs. Monitors performance, validation status, and compliance of critical systems, including certifications, HVAC qualification, process utilities, utility distribution networks, electrical systems, and environmental monitoring systems Leads cross-functional collaboration with Facilities, R&D, Quality, Validation, EHS, and IT to define and implement infrastructure solutions. Develops and maintains maintenance strategies, corrective maintenance plans, contracts, and statements of work; supports updates to drawings and engineering specifications Supports administration and continuous improvement of the Computerized Maintenance Management System (CMMS), including data integrity and system utilization Leads execution of complex engineering projects from design through commissioning, ensuring alignment with GMP standards and lifecycle validation requirements. Leads technical evaluations and risk assessments of mission-critical infrastructure and determines mitigation strategies to reduce operational and regulatory risk. Provides technical support for FDA inspections and regulatory audits; ensures systems and documentation remain inspection ready Participates in infrastructure-related investigations, root cause analysis, deviation resolution, and corrective and preventive actions Provides technical leadership, coaching, and mentorship to engineers and facilities staff; may lead indirect or matrixed teams. Communicates system performance, risks, and project updates to management and cross-functional stakeholders Other duties as assigned