Principal Research Scientist I, siRNA Platform Automation

Responsibilities

• Establish and implement a high-throughput siRNA screening platform using automated liquid-handling systems.
• Serve as a subject matter expert in siRNA screening experimental design, execution, and data interpretation.
• Lead research efforts and mentor scientists to advance siRNA optimization, including sequence design and novel chemical modifications, across multiple programs.
• Generate new scientific hypotheses and proposals, improve existing screening workflows, and evaluate emerging technologies in the siRNA field.
• Communicate clearly and effectively with internal siRNA teams and cross-functional collaborators to identify needs and support platform enhancement and program advancement.
• Manage and develop a team of at least 2-3 scientists, providing technical guidance, mentorship, and day-to-day leadership to support program goals.
• BS, MS, or PhD in Molecular Biology, Biochemistry, Chemical Biology, or a related field, with typically 6+ years (PhD), 12+ years (MS), or 14+ years (BS) of relevant experience in biotech or pharma.
• Proven track record in siRNA design, in vitro screening, and potency assays with experience using automated high-throughput platforms (e.g., Hamilton, Tecan).
• Experience with assays including, but not limited to, qRT-PCR, ELISA, and flow cytometry.
• Demonstrated experience in cell culture, including the maintenance of diverse cell lines.
• Prior experience leading siRNA platform initiatives or portfolio programs.
• Experience in animal study design and downstream assays to evaluate genetic medicines is a plus.
• Exceptional interpersonal skills and the ability to build productive working relationships with diverse internal teams and external collaborators.
• Strong track record of presenting complex scientific data to internal and external stakeholders.
• Prior people management experience is a plus.
• Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law:
• We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees.
• This job is eligible to participate in our short-term and long-term incentive programs.
• AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community. Equal Opportunity Employer/Veterans/Disabled.
• US & Puerto Rico only - to learn more, visit https://www.abbvie.com/join-us/equal-employment-opportunity-employer.html
• US & Puerto Rico applicants seeking a reasonable accommodation, click here to learn more:
• https://www.abbvie.com/join-us/reasonable-accommodations.html

Benefits

Additional Information

AbbVie's Biotherapeutics and Genetic Medicine (BGM) department is seeking a highly motivated Principal Research Scientist to join our expanding siRNA team. In this role, you will partner with genetic medicine teams to establish a high-throughput siRNA screening platform that advances pipeline innovation through next-generation delivery modalities and supports the discovery of therapeutic leads across multiple disease areas.

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