Principal Infrastructure Program Manager - Onsite San Diego HQ

About the role

At Neurocrine Biosciences, we pride ourselves on having a strong, inclusive, and positive culture based on our shared purpose and values. We know what it takes to be great, and we are as passionate about our people as we are about our purpose - to relieve suffering for people with great needs. What We Do: Neurocrine Biosciences is a leading neuroscience-focused, biopharmaceutical company with a simple purpose: to relieve suffering for people with great needs. We are dedicated to discovering and developing life-changing treatments for patients with under-addressed neurological, neuroendocrine and neuropsychiatric disorders. The company's diverse portfolio includes FDA-approved treatments for tardive dyskinesia, chorea associated with Huntington's disease, classic congenital adrenal hyperplasia, endometriosis* and uterine fibroids,* as well as a robust pipeline including multiple compounds in mid- to late-phase clinical development across our core therapeutic areas. For three decades, we have applied our unique insight into neuroscience and the interconnections between brain and body systems to treat complex conditions. We relentlessly pursue medicines to ease the burden of debilitating diseases and disorders because you deserve brave science. For more information, visit neurocrine.com , and follow the company on LinkedIn , X and Facebook . ( *in collaboration with AbbVie ) The Principal IT Infrastructure Program Manager is a senior execution leader responsible for driving the successful delivery and value realization of complex, enterprise-scale technology initiatives. Operating within the Value Management Office (VMO), this role ensures disciplined program execution across infrastructure, cloud, cybersecurity, and enterprise platforms. This individual brings deep infrastructure domain expertise and structured program management rigor to lead cross-functional initiatives that are critical to business performance, regulatory compliance, and operational scalability. The role is highly execution-focused, emphasizing governance, risk management, stakeholder alignment, and measurable outcomes. Impact: Lead enterprise-wide infrastructure transformation initiatives that enable business growth and operational excellence Ensure secure, compliant, and scalable delivery of critical technology platforms in a regulated environment Drive transparency, accountability, and value realization across complex, multi-stakeholder programs Strengthen alignment between IT strategy and business objectives through disciplined execution _ Your Contributions (include, but are not limited to): Enterprise Infrastructure & Program Delivery Lead large-scale, multi-domain initiatives including cloud migrations, network modernization, data center upgrades, and managed service transitions Drive structured program execution including milestones, dependencies, RAID logs, and executive reporting Ensure delivery is on time, within scope, and aligned to enterprise roadmaps and business goals Translate technical complexity into clear business impact and decision-ready insights Infrastructure & Managed Services Design and implement scalable L1/L2 managed service models Lead vendor onboarding, transition planning, and operational readiness Establish SLA/KPI governance and service performance management frameworks Drive integration between infrastructure monitoring platforms and ITSM systems (e.g., ServiceNow) Implement runbooks, escalation models, and operational accountability structures Governance, Risk & Compliance Establish and maintain program governance cadence including executive-level reporting Identify and mitigate cross-domain risks across infrastructure, cybersecurity, and compliance Ensure validation, regulatory, and security requirements are embedded into delivery plans Maintain documentation and traceability to support audit readiness in regulated environments Vendor & Financial Management Manage strategic vendor relationships across cloud, network, and infrastructure providers Drive vendor accountability through structured governance forums Track budgets, forecast financial impact, and support cost optimization initiatives Ensure resource and capacity planning aligns with program delivery needs Business & Stakeholder Partnership Partner with IT and business leaders to align infrastructure solutions with enterprise needs Translate business requirements into scalable, compliant technology solutions Drive alignment across Cybersecurity, Architecture, Engineering, and Operations teams Communicate effectively with executive stakeholders to influence decisions and remove barriers