Sr. Principal Scientist, Pharmacometrics

About the role

Neurocrine Biosciences is a leading biopharmaceutical company with a simple purpose: to relieve suffering for people with great needs. We are dedicated to discovering, developing and commercializing life-changing treatments for patients with under-addressed neurological, psychiatric, endocrine and immunological disorders. The company's diverse portfolio includes FDA-approved treatments for tardive dyskinesia, chorea associated with Huntington's disease, classic congenital adrenal hyperplasia, hyperphagia in patients with Prader-Willi syndrome, endometriosis* and uterine fibroids*, as well as a robust pipeline including multiple compounds in mid- to late-phase clinical development across our core therapeutic areas. For more than three decades, we have applied our unique insight into neuroscience and the interconnections between brain and body systems to treat complex conditions. We relentlessly pursue medicines to ease the burden of debilitating diseases and disorders, because you deserve brave science. For more information, visit neurocrine.com , and follow the company on LinkedIn , X , Facebook and YouTube . ( *in collaboration with AbbVie ) The Sr. Principal Scientist, Pharmacometrics leads the pharmacokinetic (PK) and pharmacodynamic (PD) modeling and simulation (M&S) efforts that drive the clinical development of Neurocrine's small- and large-molecule programs. This role provides strategic expertise in PK/PD methodology, performs or oversees pharmacometric analyses, and clearly communicates findings to cross-functional stakeholders. It also contributes to the design and execution of the Clinical Pharmacology and Pharmacometrics Development Plan. _ Your Contributions (include, but are not limited to): By applying innovative quantitative approaches to guide key development decisions, the Sr. Principal Scientist enhances program efficiency, scientific quality, and regulatory readiness Lead pharmacometrics tasks and serve as function lead for assigned clinical development program. Recommend strategic direction for modeling and simulation activities for various projects Independently conduct and report population PK, PK/PD, and Exposure-Response analyses to support dose selection, clinical trial design and regulatory submissions Oversee the design and reporting of M&S analyses conducted by external Contract Research Organizations (CROs) Contribute to the M&S sections for internal decision-making boards, regulatory documents, interactions and responses Prepare posters, publications, presentations for internal and external conferences in quantitative pharmacology and pharmacometrics science Performs other duties as assigned