Perform hands-on formulation and drug product process development for mRNA-LNP therapeutics, with additional involvement in AAV gene therapy and protein drug product development.
Design and execute experiments to develop stable and effective drug product formulations, including excipient selection, concentration optimization, and compatibility studies; build internal drug product process development capabilities and produce materials to supply non-clinical studies.
Develop and scale up drug product manufacturing processes, considering critical process parameters (CPPs) and critical quality attributes (CQAs); apply statistical analysis and experimental design to optimize process parameters and maximize product yield and quality.
Conduct stability testing to assess the long-term integrity of drug products under various storage conditions and identify potential degradation pathways.
Collaborate with CDMOs to optimize and improve drug product manufacturing processes, support scale-up, and contribute to in-process control strategies; provide technical support for GMP manufacturing activities including document review.
Maintain accurate laboratory records, document experimental protocols and results, and contribute to development reports and regulatory submissions.
Stay current with industry trends, emerging technologies, and regulatory guidelines to support continuous process improvement and compliance.
Actively contribute to a team culture of continuous improvement, ownership, professional growth, and inclusion.
Requirements
Scientist Level Reqrurement: Ph.D. in chemical engineering, biochemical engineering, biotechnology, pharmaceutical sciences, or a related field with 2-3 years of relevant industry experience
Senior Research Associate Requirement: Master's degree in a related discipline with a minimum of 6 years of relevant industry experience in drug product process development
Hands-on experience with mRNA-LNP formulation and/or process development is strongly preferred.
Experience with protein therapeutics and/or AAV gene therapy formulation development is a plus.
Experience with formulation development, process optimization, and drug product development
Experience with drug product unit operations (e.g., filling, filtration, mixing), including scale-down model development, characterization, and scale-up.
Understanding of the physical and chemical stability of biologics and how process-related stresses impact product quality.
Strong problem-solving skills with the ability to independently design experiments, interpret complex data sets, and communicate findings clearly.
Ability to thrive in a dynamic, fast-paced environment, adapting readily to shifting priorities with a willingness to develop new technical skills and to work across multiple therapeutic modalities.
Excellent written and verbal communication skills; ability to collaborate effectively in a diverse, global, cross-functional organization and a commitment to diversity, equity, and belonging.
This is a full-time onsite role (five days per week) in Redwood City, CA, with ad-hoc flexibility.
Final job le
Benefits
Health insuranceEquity / stock options
Additional Information
Our Mission
Our mission is to restore cell health and resilience through cell rejuvenation to reverse disease, injury, and the disabilities that can occur throughout life.
For more information, see our website at altoslabs.com.
Our Value
Our Single Altos Value: Everyone Owns Achieving Our Inspiring Mission .
Diversity at Altos
Altos Labs has been named one of the Top 3 Biotech Companies and ranked for the second year on the Forbes 2026 Best Startups in America list. At Altos, exceptional scientists and industry leaders from around the world work together to advance a shared mission. Our intentional focus is on Belonging, so that all employees know that they are valued for their unique perspectives. We are all accountable for sustaining a diverse and inclusive environment.
What You Will Contribute To Altos
We believe that diverse perspectives are foundational to scientific innovation and inquiry. At Altos, exceptional scientists and industry leaders from around the world work together to advance a shared mission. Our intentional focus is on Belonging, so that all employees know that they are valued for their unique perspectives. We are all accountable for sustaining a diverse and inclusive environment.
What You Will Contribute To Altos
We are seeking a highly motivated and hands-on Scientist to join the Drug Product Process Development team within Technical Operations at the Institute of Medicine. This is a predominantly bench-based role; the successful candidate will independently design and execute experiments daily, advancing mRNA-LNP,AAV and Protein-based therapeutic programs. Working in a dynamic and cross-functional environment, this scientist will perform formulation and drug product process development, and provide technical support for outsourced GMP manufacturing activities.
Altoslabs · San Francisco Bay Area, CA