The assignment potentially includes one or a combination of the following responsibilities:
The candidate will build and optimize computational models with the goal of refining transcriptomic markers of liver injury and developing in silico and in vitro screening tools for liver toxicity assessment.
The candidate will relate in vivo gene expression signatures predictive of injuries to transcriptomic data derived from in vitro liver systems.
The candidate will develop complex cell cultures and validate gene expression changes using qPCR or Luminex panels and functional changes using high-content imaging to build in vitro-in vivo correlation of identified markers.
Expected day-to-day duties:
The candidate will be expected to apply best practices and document their computational and experimental work.
The candidate will regularly present their progress in formal and informal settings to colleagues.
The candidate will interface with colleagues in PISA as well as other functional departments, including Data & Computational Sciences, Pharmacology, Formulation, and DMPK.
The candidate must have the ability to work independently and collaboratively in a multidisciplinary team.
What you will need to succeed:
Required:
Pursuing a PhD in any of the following areas: biology, biomedical sciences, computational biology, molecular biology, cell biology, or related fields.
Extensive experiences in statistics and computational modeling (e.g., mach
Benefits
Paid time offFlexible scheduleEquity / stock options
Additional Information
Job Description
Job Description
Kickstart Your Career at Vertex!
Are you ready to make a real impact? At Vertex, our mission is to tackle serious diseases and to change lives, for the better, for the future. Our aim is to give you the skills, insights, and career guidance to be an important part of that future; to turn your potential into progression. As a Vertex intern or co-op, you'll work on meaningful projects, collaborate with talented teams, and learn from industry leaders. We're passionate about innovation, inclusion, and supporting your growth-inside and outside the lab.
Why Vertex?
Real Projects: You'll work on assignments that make a real impact, not just busy work.
Mentorship & Networking: Connect with leaders and peers who want to see you succeed through professional networks, connections, and collaborations that will shape your longer-term career.
Flexible & Supportive: We offer flexible work options with Flex @ Vertex and prioritize your wellbeing.
Inclusive Culture: Collaboration and inclusion are embedded in everything we do.
Career Launchpad: Build skills, explore career paths, and get guidance for your future career.
Ready to apply? Submit your application and let's turn possibilities into reality!
Important Notice Regarding Internship and Co-op Inquiries
At Vertex Pharmaceuticals, we are committed to providing a fair and structured recruitment process for all students interested in internship and co-op opportunities. To ensure consistency and equity, all student applications must go through our Early Talent Acquisition Team.
Due to the high volume of interest, we are unable to respond to individual solicitation. Direct solicitation to Vertex employees- including senior leaders via email will result in removal from the recruiting process.
We appreciate your enthusiasm and interest in Vertex. To be considered for internship or co-op roles, please apply directly through our official application channels. ( https://www.vrtx.com/careers/career-growth-and-opportunities/co-ops/ )
Thank you for respecting our process and helping us maintain a fair experience for all candidates.
Vertex Pharmaceuticals · San Diego, CA